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<i>In vitro</i>and<i>in vivo</i>small intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences

23 Aug 2011

Abstract excerpt

Intestinal first-pass metabolism has a great impact on the bioavailability of cytochrome P450 3A4 (CYP3A) and/or uridine 5'-diphosphate (UDP)-glucoronosyltranferase (UGT) substrates in humans. In vitro and in vivo intestinal metabolism studies are essential for clarifying pharmacokinetics in animal species and for predicting the effects of human intestinal metabolism. We review species differences in intestinal...

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PMID: 21859377
DOI: 10.3109/03602532.2011.597401

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