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Article

Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells.

Mechanisms of ageing and development - 1 Dec 2019

Li Xiao, Ahmad Usama Sharif, Huang Yunying, Uttagomol Jutamas, Rehman Ambreen, Zhou Ke, Warnes Gary, McArthur Simon, Parkinson Eric Kenneth, Wan H

Abstract excerpt

Kidney disease prevalence increases with age, with a common feature of the disease being defects in the epithelial tight junctions. Emerging evidence suggests that the desmosomal adhesion protein Desmoglein-3 (Dsg3) functions beyond the desmosomal adhesion and plays a role in regulating the fundamental pathways that govern cell fate decisions in response to environmental chemical and mechanical stresses. In this...

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PMID: 31678215
DOI: 10.1016/j.mad.2019.111174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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