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Article

Deiodinases, organic anion transporter polypeptide polymorphisms and ischemic stroke outcomes.

Journal of the neurological sciences - 15 Dec 2019

Taroza Saulius, Rastenytė Daiva, Podlipskytė Aurelija, Patamsytė Vaiva, Mickuvienė Narseta

Abstract excerpt

BACKGROUND: Ischemic stroke is a major cause of premature death and chronic disability worldwide, and individual variation in functional outcome is strongly influenced by genetic factors. Neuroendocrine signaling by the hypothalamic-hypophyseal-thyroid axis is a critical regulator of post-stroke pathogenesis, suggesting that allelic variants in thyroid hormone (TH) signaling can influence stroke outcome. AIM: To...

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Identifiers

PMID: 31677555
DOI: 10.1016/j.jns.2019.116457

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