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Article

TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels

4 Jun 2008

Abstract excerpt

The Wilms tumor gene WT1 encodes a zinc-finger transcription factor that is inactivated in a subset of pediatric kidney cancers. During embryogenesis, WT1 is expressed in a time- and tissue-specific manner in various organs including gonads and kidney but also in the hematopoietic system. Although widely regarded as a tumor suppressor gene, wild-type WT1 is overexpressed in a variety of hematologic malignancies,...

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PMID: 18535006
DOI: 10.1093/nar/gkn356

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