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Article

S-Homocysteinylation effects on transthyretin: worsening of cardiomyopathy onset.

Biochimica et biophysica acta. General subjects - 1 Jan 2020

Leri Manuela, Rebuzzini Paola, Caselli Anna, Luti Simone, Natalello Antonino, Giorgetti Sofia, Marchese Loredana, Garagna Silvia, Stefani Massimo, Paoli Paolo, Bucciantini Monica

Abstract excerpt

BACKGROUND: L-Homocysteine (Hcy) is a non-proteinogenic α-amino acid synthesized from dietary methionine. In healthy humans, high Hcy levels are a risk factor for cardiovascular diseases, stroke and type 2 diabetes. A recent study reports that Hcy reacts with Cys10 of transthyretin (TTR), generating a stable covalent adduct. However, to date the effect of S-homocysteinylation on TTR conformational stability...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31676294
DOI: 10.1016/j.bbagen.2019.129453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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