Article
Curcumin could reduce the monomer of TTR with Tyr114Cys mutation via autophagy in cell model of familial amyloid polyneuropathy.
Drug design, development and therapy - 1 Jan 2014
Li Hui, Zhang Yu, Cao Li, Xiong Ran, Zhang Bei, Wu Li, Zhao Zongbo, Chen Sheng-Di
Abstract excerpt
Transthyretin (TTR) familial amyloid polyneuropathy (FAP) is an autosomal dominant inherited neurodegenerative disorder caused by various mutations in the transthyretin gene. We aimed to identify the mechanisms underlying TTR FAP with Tyr114Cys (Y114C) mutation. Our study showed that TTR Y114C mutation led to an increase in monomeric TTR and impaired autophagy. Treatment with curcumin resulted in a significant...
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