Article

AUTOTAC-mediated targeted degradation of transthyretin aggregates ameliorates hereditary transthyretin amyloidosis

2026-02-24

Abstract excerpt

Hereditary transthyretin amyloidosis (hATTR) is characterized by extracellular deposition of amyloidogenic transthyretin (TTR) aggregates, yet the mechanisms governing their clearance remains poorly understood. Here, we identify a key role for the N-degron pathway in lysosomal degradation of the pathogenic TTR V30M variant. Misfolded intracellular TTR V30M was rapidly secreted and subsequently re-entered within...

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Literature Corpus work: a558fb64-8b13-59a2-bef4-a85abc660a9f
DOI: 10.64898/2026.02.23.707350

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