Article
The Regulatory Mechanism of Transthyretin Irreversible Aggregation through Liquid-to-Solid Phase Transition.
International journal of molecular sciences - 13 Feb 2023
Duan Guangfei, Li Yanqin, Ye Meimei, Liu Hexin, Wang Ning, Luo Shizhong
Abstract excerpt
Transthyretin (TTR) aggregation and amyloid formation are associated with several ATTR diseases, such as senile systemic amyloidosis (SSA) and familial amyloid polyneuropathy (FAP). However, the mechanism that triggers the initial pathologic aggregation process of TTR remains largely elusive. Lately, increasing evidence has suggested that many proteins associated with neurodegenerative diseases undergo...
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