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Noninvasive prenatal paternity testing by means of SNP-based targeted sequencing.

Prenatal diagnosis - 1 Mar 2020

Tam Jacqueline Chor Wing, Chan Yee Man, Tsang Shui Ying, Yau Chung In, Yeung Shuk Ying, Au Ka Ki, Chow Chun Kin

Abstract excerpt

OBJECTIVE: To develop a method for noninvasive prenatal paternity testing based on targeted sequencing of single nucleotide polymorphisms (SNPs). METHOD: SNPs were selected based on population genetics data. Target-SNPs in cell-free DNA extracted from maternal blood (maternal cfDNA) were analyzed by targeted sequencing wherein target enrichment was based on multiplex amplification using QIAseq Targeted DNA Panels...

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Identifiers

PMID: 31674029
DOI: 10.1002/pd.5595
PMCID: PMC7154534

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