Noninvasive Prenatal Paternity Testing (NIPAT) through Maternal Plasma DNA Sequencing: A Pilot Study.

doi:10.1371/journal.pone.0159385

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Article

Noninvasive Prenatal Paternity Testing (NIPAT) through Maternal Plasma DNA Sequencing: A Pilot Study.

PloS one - 1 Jan 2016

Jiang Haojun, Xie Yifan, Li Xuchao, Ge Huijuan, Deng Yongqiang, Mu Haofang, Feng Xiaoli, Yin Lu, Du Zhou, Chen Fang, He Nongyue

Abstract excerpt

Short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) have been already used to perform noninvasive prenatal paternity testing from maternal plasma DNA. The frequently used technologies were PCR followed by capillary electrophoresis and SNP typing array, respectively. Here, we developed a noninvasive prenatal paternity testing (NIPAT) based on SNP typing with maternal plasma DNA sequencing. We...

Topics

DNA
Female
Humans
Male
Microsatellite Repeats
Paternity
Pilot Projects
Polymorphism, Single Nucleotide

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PMID: 27631491
DOI: 10.1371/journal.pone.0159385
PMCID: PMC5025199

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