Article
Noninvasive fetal genotyping of paternally inherited alleles using targeted massively parallel sequencing in parentage testing cases.
Transfusion - 1 Jun 2017
Yang Donggui, Liang Hao, Gao Yu, Lin Shaobin, He Zhiming, Gao Jun, Sun Hongyu, Li Qing, Ma Xiaoyan, Ou Xueling
Abstract excerpt
BACKGROUND: Researchers have sought to develop a noninvasive protocol for paternity analysis that uses fetal cell-free DNA (cfDNA) in maternal plasma. Massively parallel sequencing (MPS) is expected to overcome this challenge because it enables the analysis of millions of DNA molecules at a single-base resolution. STUDY DESIGN AND METHODS: Seven women were involved in prenatal paternity testing cases. Before...
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