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Article

Genetic and clinical determinants influencing warfarin dosing in children with heart disease.

Pediatric cardiology - 1 Apr 2013

Nguyen Nguyenvu, Anley Peter, Yu Margaret Y, Zhang Gang, Thompson Alexis A, Jennings Larry J

Abstract excerpt

Warfarin is a common anticoagulant with narrow therapeutic window and variable anticoagulation effects. Single gene polymorphisms in cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) have been shown to impact warfarin dosing in adults. Insufficient data exists on genetic and clinical factors which influence warfarin dosing in children. Pediatric patients with heart disease who received...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23183958
DOI: 10.1007/s00246-012-0592-1

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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