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Article

Disentangling the lifespans of hepatitis C virus-infected cells and intracellular vRNA replication-complexes during direct-acting anti-viral therapy.

Journal of viral hepatitis - 1 Mar 2020

Cardozo Erwing Fabian, Ji Dong, Lau George, Schinazi Raymond F, Chen Guo-Feng, Ribeiro Ruy M, Perelson Alan S

Abstract excerpt

The decay rate of hepatitis C virus (HCV)-infected cells during therapy has been used to determine the duration of treatment needed to attain a sustained virologic response, but with direct-acting anti-virals (DAA), this rate has been difficult to estimate. Here, we show that it is possible to estimate it, by simultaneously analysing the viral load and alanine aminotransferase (ALT) kinetics during combination...

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Source

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Identifiers

PMID: 31670859
DOI: 10.1111/jvh.13229
PMCID: PMC7031045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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