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Article

Second-Phase Hepatitis C Plasma Viral Kinetics Directly Reflects Reduced Intrahepatic Burden of Hepatitis C Virus.

The Journal of infectious diseases - 11 Aug 2023

Sachithanandham Jaiprasath, Balagopal Ashwin, Leep-Lazar Julia, Quinn Jeffrey, Bowden Kenneth, Ward Kathleen, Ribeiro Ruy M, Sulkowski Mark S

Abstract excerpt

BACKGROUND: Mathematical models explain how antivirals control viral infections. Hepatitis C virus (HCV) treatment results in at least 2 phases of decline in viremia. The first phase reflects clearance of rapidly produced virions. The second phase is hypothesized to derive from loss of infected cells but has been challenging to prove. METHODS: Using single-cell methods, we quantified the number of hepatitis C...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36722133
DOI: 10.1093/infdis/jiad025
PMCID: PMC10420397

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