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Article

Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase.

Molecular endocrinology (Baltimore, Md.) - 1 Oct 2007

Pandey Amit V, Kempná Petra, Hofer Gaby, Mullis Primus E, Flück Christa E

Abstract excerpt

Mutations in NADPH P450 oxidoreductase (POR) cause a broad spectrum of human disease with abnormalities in steroidogenesis. We have studied the impact of P450 reductase mutations on the activity of CYP19A1. POR supported CYP19A1 activity with a calculated Km of 126 nm for androstenedione and a Vmax of 1.7 pmol/min. Mutations R457H and V492E located in the FAD domain of POR that disrupt electron transfer caused a...

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PMID: 17595315
DOI: 10.1210/me.2007-0245

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POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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