Article
Risk of chemotherapy-associated liver injury (CALI) in PNPLA3 p.148M allele carriers: Preliminary results of a transient elastography-based study.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Jan 2020
Casper Markus, Zimmermann Simone, Weber Susanne N, Arslanow Anita, Lammert Frank, Krawczyk Marcin
Abstract excerpt
BACKGROUND AND AIMS: Liver steatosis is one of the side effects of chemotherapy. The PNPLA3 p.I148M, TM6SF2 p.E167K and MBOAT7 p.G17E variants represent genetic determinants for progressive liver diseases. Here, we investigate their association with chemotherapy-associated steatosis. PATIENTS AND METHODS: Prospectively, we recruited 87 patients undergoing systemic chemotherapy for gastrointestinal cancers....
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