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Article

Transcriptional Signature Derived from Murine Tumor-Associated Macrophages Correlates with Poor Outcome in Breast Cancer Patients.

Cell reports - 29 Oct 2019

Tuit Sander, Salvagno Camilla, Kapellos Theodore S, Hau Cheei-Sing, Seep Lea, Oestreich Marie, Klee Kathrin, de Visser Karin E, Ulas Thomas, Schultze Joachim L

Abstract excerpt

Tumor-associated macrophages (TAMs) are frequently the most abundant immune cells in cancers and are associated with poor survival. Here, we generated TAM molecular signatures from K14cre;Cdh1flox/flox;Trp53flox/flox (KEP) and MMTV-NeuT (NeuT) transgenic mice that resemble human invasive lobular carcinoma (ILC) and HER2+ tumors, respectively. Determination of TAM-specific signatures requires comparison with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mammary Neoplasms, Animal

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Identifiers

PMID: 31665635
DOI: 10.1016/j.celrep.2019.09.067
PMCID: PMC7057267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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