Article
Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer.
Cancer research - 1 Jan 2020
Ritter Jessica L, Zhu Zehua, Thai Tran C, Mahadevan Navin R, Mertins Philipp, Knelson Erik H, Piel Brandon P, Han Saemi, Jaffe Jacob D, Carr Steven A, Barbie David A, Barbie Thanh U
Abstract excerpt
Triple-negative breast cancer (TNBC) is a heterogeneous disease enriched for mutations in PTEN and dysregulation of innate immune signaling. Here, we demonstrate that Rab7, a recently identified substrate of PTEN phosphatase activity, is also a substrate of the innate immune signaling kinases TANK-binding kinase 1 (TBK1)/IκB kinase ε (IKKε) on the same serine-72 (S72) site. An unbiased search for novel TBK1/IKKε...
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