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Article

Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy

29 Oct 2019

Abstract excerpt

Mitochondrial quality control (MQC) is crucial for regulating CNS homeostasis, and its disruption has been implicated in the pathogenesis of some of the most common neurodegenerative diseases. In healthy tissues, the maintenance of MQC depends upon an exquisite balance between mitophagy (removal of damaged mitochondria by autophagy) and biogenesis (de novo synthesis of mitochondria). Here, we show that mitophagy...

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PMID: 31661466
DOI: 10.1172/jci.insight.129760

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