Article
herg1b expression as a potential specific marker in pediatric acute myeloid leukemia patients with HERG 897K/K genotype.
Pediatric hematology and oncology - 1 Apr 2015
Erdem Merve, Tekiner Tugce Ayca, Fejzullahu Arta, Akan Gokce, Anak Sema, Saribeyoglu Ebru Tugrul, Ozbek Ugur, Atalar Fatmahan
Abstract excerpt
Human ether-a-go-go related gene (herg) encoding HERG K(+) channel has been demonstrated in many previous studies with its association to cell cycle progression and growth in tumor cells. The upregulated expression of HERG K+ channels was determined in different tumor types. Furthermore, not only full-length transcript herg1 but also a truncated isoform herg1b was shown to be expressed in cancer cells. In this...
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