Article
Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction.
Atherosclerosis - 1 Jun 2013
van Setten Jessica, Isgum Ivana, Smolonska Joanna, Ripke Stephan, de Jong Pim A, Oudkerk Matthijs, de Koning Harry, Lammers Jan-Willem J, Zanen Pieter, Groen Harry J M, Boezen H Marike, Postma Dirkje S, Wijmenga Cisca, Viergever Max A, Mali Willem P Th M, de Bakker Paul I W
Abstract excerpt
Arterial calcification is a well-known risk factor for coronary artery disease (CAD) and myocardial infarction (MI). We performed a genome-wide association study on coronary artery calcification and aortic calcification as intermediate traits for CAD/MI. We tested ∼2.5 million SNPs for association with coronary artery calcification and aortic calcification in 2620 male individuals of the NELSON trial, who...
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