Article
Natural human genetic variation determines basal and inducible expression of PM20D1, an obesity-associated gene.
Proceedings of the National Academy of Sciences of the United States of America - 12 Nov 2019
Benson Kiara K, Hu Wenxiang, Weller Angela H, Bennett Alexis H, Chen Eric R, Khetarpal Sumeet A, Yoshino Satoshi, Bone William P, Wang Lin, Rabinowitz Joshua D, Voight Benjamin F, Soccio Raymond E
Abstract excerpt
PM20D1 is a candidate thermogenic enzyme in mouse fat, with its expression cold-induced and enriched in brown versus white adipocytes. Thiazolidinedione (TZD) antidiabetic drugs, which activate the peroxisome proliferator-activated receptor-γ (PPARγ) nuclear receptor, are potent stimuli for adipocyte browning yet fail to induce Pm20d1 expression in mouse adipocytes. In contrast, PM20D1 is one of the most strongly...
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