Article
Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus.
Viruses - 10 Oct 2019
Fahnøe Ulrik, Pedersen Anders Gorm, Johnston Camille Melissa, Orton Richard J, Höper Dirk, Beer Martin, Bukh Jens, Belsham Graham J, Rasmussen Thomas Bruun
Abstract excerpt
Vaccines against classical swine fever have proven very effective in protecting pigs from this deadly disease. However, little is known about how vaccination impacts the selective pressures acting on the classical swine fever virus (CSFV). Here we use high-throughput sequencing of viral genomes to investigate evolutionary changes in virus populations following the challenge of naïve and vaccinated pigs with the...
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