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Experimental evidence of vaccine-driven evolution of porcine reproductive and respiratory syndrome virus type 2

1 Jan 2025

Abstract excerpt

Abstract Despite extensive use of vaccination, porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2) continues to evolve, likely driven by escape from natural or vaccine-derived immunity. However, direct evidence of vaccine-induced evolutionary pressure remains limited. Here, we tracked the evolution of PRRSV-2 sublineage 1A strain IA/2014 (variant 1A-unclassified) genome from infection chains of...

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PMID: 40831531
DOI: 10.1093/ve/veaf056

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