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Article

CD137-CD137L Signaling Affects Angiogenesis by Mediating Phenotypic Conversion of Macrophages.

Journal of cardiovascular pharmacology - 1 Feb 2020

Xu Yao, Yan Yang, Geng Tianxin, Wang Cuiping, Xu Yu, Yang Ping, Yan Jinchuan

Abstract excerpt

BACKGROUND: Angiogenesis in atherosclerotic plaque is an important factor causing plaque hemorrhage, vulnerability, and rupture, and different phenotypes of macrophages have different effects on angiogenesis. Our previous study has demonstrated CD137-CD137L signaling, a pair of inflammatory costimulatory molecules, can promote angiogenesis in atherosclerotic plaque. Therefore, we aimed to investigate whether this...

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PMID: 31651672
DOI: 10.1097/FJC.0000000000000772

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