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Article

Macrophages of diverse phenotypes drive vascularization of engineered tissues.

Science advances - 1 May 2020

Graney P L, Ben-Shaul S, Landau S, Bajpai A, Singh B, Eager J, Cohen A, Levenberg S, Spiller K L

Abstract excerpt

Macrophages are key contributors to vascularization, but the mechanisms behind their actions are not understood. Here, we show that diverse macrophage phenotypes have distinct effects on endothelial cell behavior, with resulting effects on vascularization of engineered tissues. In Transwell coculture, proinflammatory M1 macrophages caused endothelial cells to up-regulate genes associated with sprouting...

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Identifiers

PMID: 32494664
DOI: 10.1126/sciadv.aay6391
PMCID: PMC7195167

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