Article
Human Placenta-Derived Mesenchymal Stromal-Like Cells Enhance Angiogenesis via T Cell-Dependent Reprogramming of Macrophage Differentiation.
Stem cells (Dayton, Ohio) - 1 Jun 2017
He Shuyang, Gleason Joseph, Fik-Rymarkiewicz Ewa, DiFiglia Andrea, Bharathan Mini, Morschauser Andrew, Djuretic Ivana, Xu Yan, Krakovsky Michael, Jankovic Vladimir, Buensuceso Charito, Edinger James, Herzberg Uri, Hofgartner Wolfgang, Hariri Robert
Abstract excerpt
Peripheral arterial disease (PAD) is a leading cause of limb loss and mortality worldwide with limited treatment options. Mesenchymal stromal cell (MSC) therapy has demonstrated positive effects on angiogenesis in preclinical models and promising therapeutic efficacy signals in early stage clinical studies; however, the mechanisms underlying MSC-mediated angiogenesis remain largely undefined. Here, we...
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