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Article

Major challenges in accurate mutation detection of multifocal lung adenocarcinoma by next-generation sequencing.

Cancer biology & therapy - 1 Jan 2020

Qiu Tian, Li Weihua, Zhang Fanshuang, Wang Bingning, Ying Jianming

Abstract excerpt

Background: Many patients with advanced non-small cell lung cancer manifested with metastasis, and molecular heterogeneity may exhibit between primary and metastatic tumors. We sought to investigate the clinical detection strategy of primary and metastatic tumors in Chinese patients with NSCLC.Methods: Here, 77 paired tumors of Chinese patients with lung adenocarcinoma were analyzed, and 1836 mutation in hotspot...

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Identifiers

PMID: 31651223
DOI: 10.1080/15384047.2019.1674070
PMCID: PMC7012153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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