Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel ALK Fusion in Pediatric Medullary Thyroid Carcinoma.

Thyroid : official journal of the American Thyroid Association - 1 Nov 2019

Hillier Kirsty, Hughes Amy, Shamberger Robert C, Shusterman Suzanne, Perez-Atayde Antonio R, Wassner Ari J, Iafrate Anthony John, Dubuc Adrian, Janeway Katherine A, Rothenberg S Michael, Cox Michael C, Randolph Gregory W, Wirth Lori J, Tsai Harrison, Church Alanna, DuBois Steven G

Abstract excerpt

Medullary thyroid carcinoma (MTC) is most commonly associated with RET gene mutations. ALK fusions have rarely been described, although not previously in pediatrics and not previously partnered with CCDC6 in MTC or any other cancer. A 10-year-old boy with progressive stridor was found to have metastatic MTC, including lung, lymph node, and adrenal metastases. Baseline calcitonin was 6703 pg/mL. While molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaplastic Lymphoma Kinase
Share to Calcitonin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carbazoles

Share to Carcinoma, Neuroendocrine

Share to Gene Fusion

Share to Molecular Diagnostic Techniques

Share to Piperidines

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 31650892
DOI: 10.1089/thy.2019.0041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel ALK Fusion in Pediatric Medullary Thyroid Carcinoma.PMID 31650892Read ↗

NTRK-fusions in pediatric thyroid tumors: Current state and future perspectives.Semantic proximity Read ↗

RET, NTRK, ALK, BRAF, and MET Fusions in a Large Cohort of Pediatric Papillary Thyroid Carcinomas.Semantic proximity Read ↗

Case Report of CCDC149-ALK Fusion: A Novel Genetic Alteration and a Clinically Relevant Target in Metastatic Papillary Thyroid Carcinoma.Semantic proximity Read ↗

Pediatric, Adolescent, and Young Adult Thyroid Carcinoma Harbors Frequent and Diverse Targetable Genomic Alterations, Including Kinase Fusions.Semantic proximity Read ↗

Genetic Alterations in Pediatric Thyroid Cancer Using a Comprehensive Childhood Cancer Gene PanelSemantic proximity Read ↗

Molecular Alterations in Relation to Histopathological Characteristics in a Large Series of Pediatric Papillary Thyroid Carcinoma from a Single InstitutionSemantic proximity Read ↗

Sustained Response with Dose Reduced Selpercatinib in a Pediatric Patient with Metastatic NCOA4-RET Fusion Papillary Thyroid CarcinomaSemantic proximity Read ↗

The clinical aspect of NTRK-fusions in pediatric papillary thyroid cancer.Semantic proximity Read ↗

Identification of a novel GOPC-RET fusion in a patient with lung adenocarcinoma: A case reportSemantic proximity Read ↗

Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer.Semantic proximity Read ↗

RET Fusion as a Novel Driver of Medullary Thyroid CarcinomaSemantic proximity Read ↗

Medullary thyroid carcinoma in children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.