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Enhancing the anti-tumor response by combining DNA damage repair inhibitors in the treatment of solid tumors

10 May 2023

Abstract excerpt

The anti-cancer efficacy of anti-malignancy therapies is related to DNA damage. However, DNA damage-response mechanisms can repair DNA damage, failing anti-tumor therapy. The resistance to chemotherapy, radiotherapy, and immunotherapy remains a clinical challenge. Thus, new strategies to overcome these therapeutic resistance mechanisms are needed. DNA damage repair inhibitors (DDRis) continue to be investigated,...

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PMID: 37172653
DOI: 10.1016/j.bbcan.2023.188910

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