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Article

KRAS mutation in pancreatic cancer.

Seminars in oncology - 1 Feb 2021

Luo Ji

Abstract excerpt

Pancreatic cancer is a recalcitrant cancer with one of the lowest 5-year survival rates. A hallmark of pancreatic cancer is the prevalence of oncogenic mutation in the KRAS gene. The KRAS oncogene plays a critical role in the initiation and maintenance of pancreatic tumors and its signaling network represents a major target for therapeutic intervention. A number of inhibitors have been developed against kinase...

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Identifiers

PMID: 33676749
DOI: 10.1053/j.seminoncol.2021.02.003
PMCID: PMC8380752

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