Article
Influence of Genetic Interactions on Polygenic Prediction.
G3 (Bethesda, Md.) - 7 Jan 2020
Dai Zhijun, Long Nanye, Huang Wen
Abstract excerpt
Prediction of phenotypes from genotypes is an important objective to fulfill the promises of genomics, precision medicine and agriculture. Although it's now possible to account for the majority of genetic variation through model fitting, prediction of phenotypes remains a challenge, especially across populations that have diverged in the past. In this study, we designed simulation experiments to specifically...
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