Article

Molecular Basis for Reduced Cleavage Activity and Drug Resistance in D30N HIV-1 protease

2021-03-01

Abstract excerpt

Nelfinavir is one of the FDA approved HIV-1 protease inhibitors and is a part of HAART therapy for the treatment of HIV-AIDS. Nelfinavir was the first HIV-1 protease inhibitor to be approved as a Paediatric formulation. The application of HAART had resulted into significant improvement in the life of AIDS patients. However, emergence of drug resistance in HIV-1 protease limited the use of many of these drugs inclu...

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Literature Corpus work: d9d8a9fe-8b25-510a-a5af-4db563ee894f
DOI: 10.1101/2021.02.28.433284

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