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Article

ER stress and Rho kinase activation underlie the vasculopathy of CADASIL.

JCI insight - 5 Dec 2019

Neves Karla B, Harvey Adam P, Moreton Fiona, Montezano Augusto C, Rios Francisco J, Alves-Lopes Rhéure, Nguyen Dinh Cat Aurelie, Rocchicciolli Paul, Delles Christian, Joutel Anne, Muir Keith, Touyz Rhian M

Abstract excerpt

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) leads to premature stroke and vascular dementia. Mechanism-specific therapies for this aggressive cerebral small vessel disease are lacking. CADASIL is caused by NOTCH3 mutations that influence vascular smooth muscle cell (VSMC) function through unknown processes. We investigated molecular mechanisms underlying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31647781
DOI: 10.1172/jci.insight.131344
PMCID: PMC6962020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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