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Article

Tuning the lipophilicity of new ciprofloxacin derivatives in selected ESKAPE bacteria with emphasis on E. coli mutants.

Bioorganic chemistry - 1 May 2025

Cassese Emilia, Koszelewski Dominik, Brodzka Anna, Wavhal Deepak S, Kowalczyk Paweł, Ostaszewski Ryszard

Abstract excerpt

The objective of the present study was to improve the antimicrobial profile of ciprofloxacin by introducing a peptidomimetic function. A ciprofloxacin C3 carboxyl group was modified by a three-component Passerini reaction conducted under micellar conditions. The series of newly synthesized peptidomimetics was evaluated for their possible in vitro antibacterial activity toward including selected LPS-varied E. coli...

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Identifiers

PMID: 40054399
DOI: 10.1016/j.bioorg.2025.108324

Genes

C3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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