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Zosurabalpin: a novel tethered macrocyclic peptide antibiotic that kills carbapenem‐resistant Acinetobacter baumannii

1 Aug 2024

Abstract excerpt

In two recent studies published back-to-back in Nature, Bradley's and Kahne's teams reported a novel tethered macrocyclic peptide (MCP) antibiotic called zosurabalpin, which targets the LptB2FGC complex in the inner membrane to block lipopolysaccharide (LPS) transport, leading to the accumulation of this endotoxin in the cell, ultimately resulting in the death of the bacteria (Figure 1).1, 2 Zosurabalpin not only...

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PMID: 39132511
DOI: 10.1002/mco2.696

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