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Generation of simian rotavirus reassortants with diverse VP4 genes using reverse genetics

30 Oct 2019

Abstract excerpt

Species A rotaviruses (RVAs) are a major cause of gastroenteritis in animals and humans. Their genome consists of 11 segments of dsRNA, and reassortment events between animal and human strains can contribute to the high genetic diversity of RVAs. We used a plasmid-based reverse genetics system to investigate the reassortment potential of the genome segment encoding the viral outer capsid protein VP4, which is a...

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PMID: 31665098
DOI: 10.1099/jgv.0.001322

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