Construction of strains to identify novel factors for regulation of centromeric cohesion protection (CCP) and sister kinetochore mono-orientation (SKM).

doi:10.1186/s12860-019-0231-2

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Article

Construction of strains to identify novel factors for regulation of centromeric cohesion protection (CCP) and sister kinetochore mono-orientation (SKM).

BMC molecular and cell biology - 22 Oct 2019

Bharati Akhilendra Pratap, Ghosh Santanu Kumar

Abstract excerpt

BACKGROUND: Meiosis-I is a unique type of chromosome segregation where each chromosome aligns and segregates from its homolog. The mechanism of meiosis I homolog separation in different eukaryotes depends on their centromere and kinetochore architecture which in turn relies mainly on two processes, first on a specialized four protein complex known as monopolin and second, the centromeric cohesion protection...

Topics

Cell Proliferation
Chromosome Segregation
Genetic Engineering
Kinetochores
Microbial Viability
Mitosis
Phenotype
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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PMID: 31640543
DOI: 10.1186/s12860-019-0231-2
PMCID: PMC6806570

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