Article
Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment.
The Journal of clinical investigation - 2 Dec 2019
Petty Amy J, Li Ang, Wang Xinyi, Dai Rui, Heyman Benjamin, Hsu David, Huang Xiaopei, Yang Yiping
Abstract excerpt
Tumor-associated macrophages (TAMs) usually display an antiinflammatory M2-like phenotype to facilitate tumor growth. However, what drives M2 polarization of TAMs and how TAMs suppress antitumor immunity within the tumor microenvironment (TME) remain largely undefined. Using several murine tumor models, we showed that hedgehog (Hh) signaling in myeloid cells is critical for TAM M2 polarization and tumor growth....
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