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Article

BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin

21 Oct 2019

Abstract excerpt

The circadian clock and aging are intertwined. Disruption to the normal diurnal rhythm accelerates aging and corresponds with telomere shortening. Telomere attrition also correlates with increase cellular senescence and incidence of chronic disease. In this report, we examined diurnal association of White Collar 2 (WC-2) in Neurospora and BMAL1 in zebrafish and mice and found that these circadian transcription...

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Share to Circadian rhythm and melatonin
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Telomeres, Telomerase, and Senescence

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PMID: 31634367
DOI: 10.1371/journal.pone.0223803

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