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Article

MIBI-TOF: A multiplexed imaging platform relates cellular phenotypes and tissue structure.

Science advances - 1 Oct 2019

Keren Leeat, Bosse Marc, Thompson Steve, Risom Tyler, Vijayaragavan Kausalia, McCaffrey Erin, Marquez Diana, Angoshtari Roshan, Greenwald Noah F, Fienberg Harris, Wang Jennifer, Kambham Neeraja, Kirkwood David, Nolan Garry, Montine Thomas J, Galli Stephen J, West Robert, Bendall Sean C, Angelo Michael

Abstract excerpt

Understanding tissue structure and function requires tools that quantify the expression of multiple proteins while preserving spatial information. Here, we describe MIBI-TOF (multiplexed ion beam imaging by time of flight), an instrument that uses bright ion sources and orthogonal time-of-flight mass spectrometry to image metal-tagged antibodies at subcellular resolution in clinical tissue sections. We...

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Identifiers

PMID: 31633026
DOI: 10.1126/sciadv.aax5851
PMCID: PMC6785247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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