Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BIRC5/Survivin is a novel ATG12–ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells

15 Oct 2019

Abstract excerpt

BIRC5/Survivin is known as a dual cellular functions protein that directly regulates both apoptosis and mitosis in embryonic cells during embryogenesis and in cancer cells during tumorigenesis and tumor metastasis. However, BIRC5 has seldom been demonstrated as a direct macroautophagy/autophagy regulator in cells. ATG7 expression and ATG12-ATG5-ATG16L1 complex formation are crucial for the phagophore elongation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cell death mechanisms and regulation
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31612776
DOI: 10.1080/15548627.2019.1671643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BIRC5/Survivin is a novel ATG12–ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cellsPMID 31612776Read ↗

Comprehensive analysis of BIRC5: from pan-cancer analysis to experimental validation.Semantic proximity Read ↗

BIRC5 as a master regulator in HCC: unraveling its role in tumor survival and therapeutic potentialSemantic proximity Read ↗

BIRC5 Inhibition Is Associated with Pyroptotic Cell Death via Caspase3-GSDME Pathway in Lung Adenocarcinoma CellsSemantic proximity Read ↗

A comprehensive review and in silico analysis of the role of survivin (BIRC5) in hepatocellular carcinoma hallmarks: A step toward precisionSemantic proximity Read ↗

Survivin (BIRC5): Implications in cancer therapySemantic proximity Read ↗

BIRC5 is a prognostic biomarker associated with tumor immune cell infiltrationSemantic proximity Read ↗

Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCESemantic proximity Read ↗

Tumor suppressor gene<i><i>PDCD4</i></i>negatively regulates autophagy by inhibiting the expression of autophagy-related gene<i><i>ATG5</i></i>Semantic proximity Read ↗

CCAR2/DBC1 and Hsp60 Positively Regulate Expression of Survivin in Neuroblastoma CellsSemantic proximity Read ↗

Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathwaySemantic proximity Read ↗

Polymorphism of Baculoviral Inhibitor of Apoptosis Repeat-Containing 5 (BIRC5) Can Be Associated with Clinical Outcome of Non-Small Cell Lung Cancer.Semantic proximity Read ↗

Repression of BIRC5/survivin by FOXO3/FKHRL1 sensitizes human neuroblastoma cells to DNA damage-induced apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.