Article
DNA methylation as a marker of response in rheumatoid arthritis.
Pharmacogenomics - 1 Sept 2017
Nair Nisha, Wilson Anthony G, Barton Anne
Abstract excerpt
Rheumatoid arthritis (RA) is a complex disease affecting approximately 0.5-1% of the population. While there are effective biologic therapies, in up to 40% of patients, disease activity remains inadequately controlled. Therefore, identifying factors that predict, prior to the initiation of therapy, which patients are likely to respond best to which treatment is a research priority and DNA methylation is...
Topics
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents, Non-Steroidal
- Antibodies, Monoclonal
- Arthritis, Rheumatoid
- DNA Methylation
- Genetic Markers
- Humans
- Polymorphism, Single Nucleotide
- Treatment Outcome