Article
Improved characterisation of MRSA transmission using within-host bacterial sequence diversity.
eLife - 8 Oct 2019
Hall Matthew D, Holden Matthew Tg, Srisomang Pramot, Mahavanakul Weera, Wuthiekanun Vanaporn, Limmathurotsakul Direk, Fountain Kay, Parkhill Julian, Nickerson Emma K, Peacock Sharon J, Fraser Christophe
Abstract excerpt
Methicillin-resistant Staphylococcus aureus (MRSA) transmission in the hospital setting has been a frequent subject of investigation using bacterial genomes, but previous approaches have not yet fully utilised the extra deductive power provided when multiple pathogen samples are acquired from each host. Here, we used a large dataset of MRSA sequences from multiply-sampled patients to reconstruct colonisation of...
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