Considerations When Using Breast Cancer Risk Models for Women with Negative BRCA1/BRCA2 Mutation Results.

doi:10.1093/jnci/djz194

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Article

Considerations When Using Breast Cancer Risk Models for Women with Negative BRCA1/BRCA2 Mutation Results.

Journal of the National Cancer Institute - 1 Apr 2020

MacInnis Robert J, Liao Yuyan, Knight Julia A, Milne Roger L, Whittemore Alice S, Chung Wendy K, Leoce Nicole, Buchsbaum Richard, Zeinomar Nur, Dite Gillian S, Southey Melissa C, Goldgar David, Giles Graham G, McLachlan Sue-Anne, Weideman Prue C, Nesci Stephanie, Friedlander Michael L, Glendon Gord, Andrulis Irene L, John Esther M, Daly Mary B, Buys Saundra S, Phillips Kelly Anne, Hopper John L, Terry Mary Beth

Abstract excerpt

The performance of breast cancer risk models for women with a family history but negative BRCA1 and/or BRCA2 mutation test results is uncertain. We calculated the cumulative 10-year invasive breast cancer risk at cohort entry for 14 657 unaffected women (96.1% had an affected relative) not known to carry BRCA1 or BRCA2 mutations at baseline using three pedigree-based models (Breast and Ovarian Analysis of Disease...

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PMID: 31584660
DOI: 10.1093/jnci/djz194
PMCID: PMC7156937

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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