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Article

Clinically applicable models to characterize BRCA1 and BRCA2 variants of uncertain significance.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Nov 2008

Spearman Andrew D, Sweet Kevin, Zhou Xiao-Ping, McLennan Jane, Couch Fergus J, Toland Amanda Ewart

Abstract excerpt

PURPOSE: Twenty percent of individuals with a strong family and/or personal history of breast and ovarian cancer carry a deleterious mutation in BRCA1 or BRCA2. Identification of mutations in these genes is extremely beneficial for patients pursuing risk reduction strategies. Approximately 7% of individuals who have genetic testing of BRCA1 and BRCA2 carry a variant of uncertain significance (VUS), making...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18824701
DOI: 10.1200/JCO.2008.17.8228
PMCID: PMC2651073

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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