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Article

The risk of breast cancer in BRCA1 and BRCA2 mutation carriers without a first-degree relative with breast cancer.

Clinical genetics - 1 May 2018

Metcalfe K A, Lubinski J, Gronwald J, Huzarski T, McCuaig J, Lynch H T, Karlan B, Foulkes W D, Singer C F, Neuhausen S L, Senter L, Eisen A, Sun P, Narod S A

Abstract excerpt

The objective of this study was to estimate the lifetime risk of breast cancer in women with a BRCA1 or BRCA2 mutation with and without at least 1 first-degree relative with breast cancer. A total of 2835 women with a BRCA1 or BRCA2 mutation were followed. Age- and gene-specific breast cancer rates were calculated. The relative risks of breast cancer for subjects with a family history of breast cancer, compared...

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Source

Identifiers

PMID: 29206279
DOI: 10.1111/cge.13191

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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