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miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation <i>In Vitro</i> and Vascular Development <i>In Vivo</i>

18 May 2010

Abstract excerpt

The lymphatic vascular system maintains tissue fluid homeostasis, helps mediate afferent immune responses, and promotes cancer metastasis. To address the role microRNAs (miRNAs) play in the development and function of the lymphatic vascular system, we defined the in vitro miRNA expression profiles of primary human lymphatic endothelial cells (LECs) and blood vascular endothelial cells (BVECs) and identified four...

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PMID: 20479124
DOI: 10.1128/mcb.00185-10

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