Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice

27 Sept 2019

Abstract excerpt

BACKGROUND: The goal of this study was to determine if adenovirus-delivered LOXL2 protects against progressive knee osteoarthritis (OA), assess its specific mechanism of action; and determine if the overexpression of LOXL2 in transgenic mice can protect against the development of OA-related cartilage damage and joint disability. METHODS: Four-month-old Cho/+ male and female mice were intraperitoneally injected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Medical and Biological Ozone Research
Share to Microbial metabolism and enzyme function
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31569601
DOI: 10.3390/ijms20194798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in MicePMID 31569601Read ↗

LOXL2 alleviates post-traumatic knee osteoarthritis and painSemantic proximity Read ↗

LOXL2 as a protective in osteoarthritis cartilage.Semantic proximity Read ↗

Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directionsSemantic proximity Read ↗

FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritisSemantic proximity Read ↗

Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female miceSemantic proximity Read ↗

Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes.Semantic proximity Read ↗

Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and Tgfβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritisSemantic proximity Read ↗

Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and TGFβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritisSemantic proximity Read ↗

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritisSemantic proximity Read ↗

IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in miceSemantic proximity Read ↗

Silencing of Wnt5a prevents interleukin-1β-induced collagen type II degradation in rat chondrocytesSemantic proximity Read ↗

Osteoarthritis: New Insights in Animal ModelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.