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Article

Hypoxic niches are endowed with a protumorigenic mechanism that supersedes the protective function of PTEN

27 Sept 2019

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide and is characterized by a fast-paced growth. Like other solid tumors, the HNSCC growth rate results in the development of hypoxic regions identified by the expression of hypoxia-inducible factor 1α (HIF-1α). Interestingly, clinical data have shown that pharmacological induction of intratumoral hypoxia caused an unexpected...

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PMID: 31560860
DOI: 10.1096/fj.201900722r

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